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Aminoacyl-tRNA Synthetase (AaRS); a promising target for antibiotic drugs
Chimaobi J. Ononamadu* , Onyinye S. Udoh* (2009)
Dept of Applied biochemistry, Nnamdi Azikiwe University. Awka. Nigeria. ( Review Article)
Correspondence to: Ononamadu Chimaobi., +2348037202476
Aminoacyl-tRNA synthetase (AaRs) enzymes are essentially critical in the biosynthesis of proteins. They catalyze the synthesis of aminoacyl-tRNAs (aa-rRNA).There is a growing evidence that aminoacyl-tRNA synthetases could represent a broad target for antibiotics and antibacterial agents with the growing emergence of AaRs inhibitors like, Indolmycin (which targets TrpRs) Chuangxinmycin (which targets ThrRs ) Granaticin (which targets leuRs ) Furanomycin (which targets IleRs), Ochratoxin A (which targets ProRS, ). REP 8839 (which targets metRS) SB- 219383 (which targets TyrRs) and Mupirocin Presently, mupirocin is the only commercially available antibiotic that inhibits bacterial AaRs, and it has proven to be a potent competitive inhibitor of Iso-Leucyl tRNA synthetase in Staphylococcus aureus. Despite the high potency, high and low level resistances have been reported in mupirocin clinical use as a result of acquired foreign gene (mupA) and point mutation respectively. The advent and structural modeling of mupirocin has served as a paradigm for the clinical development and deployment of some other AaRs. This work reviewed the prospect of AaRS inhibitors as strong antibiotics.
Keywords: Aminoacyl-tRNA synthetase (AaRs), Staphylococcus aureus (S. aureus), aminoacyl-tRNAs (aa-rRNA) Drug, antibiotic,mechanism,inhibitor, drug resistance.
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